Table 3 Features of depression and bipolar disorder in normal range participants (2500–4500 g)
Relative risk ratios (95% CI)P
 Unadjusted (n=83 172)0.93 (0.91–0.95)<0.001
 Adjusted for potential confoundersa (n=71 591)0.98 (0.96–1.00)0.074
 Adjusted for potential physical disease mediatorsb (n=71 591)0.99 (0.97–1.01)0.387
Bipolar disorder
 Unadjusted (n=83 545)0.93 (0.84–1.03)0.187
 Adjusted for potential confoundersa (n=71 953)0.91 (0.82–1.02)0.091
 Adjusted for potential physical disease mediatorsb (n=71 953)0.93 (0.83–1.03)0.160
  • a Adjusted for year of birth, Townsend deprivation score, ethnicity, gender, maternal smoking and maternal depression.

  • b Additionally adjusted for hypertension, heart/cardiac problems, stroke, perivascular disease, type-2 diabetes, chronic obstructive pulmonary disease and osteoporosis.