Box 1 Features of an ideal antidepressant
  • Sustained efficacy that minimises frequency of dosing and enhances compliance

  • Well tolerated with minimal short-term and longer term side-effects

  • Safe at clinical doses and ideally safe during overdose

  • Simple for clinicians to administer and for patients to take, maximising compliance

  • Minimal discontinuation symptoms, low-misuse potential and non-addictive

  • Widely available and accessible, with good cost-effectiveness

  • Effective at population level: community and/or primary care