Table 2 Demographic and clinical characteristics
MDD patientsHealthy controlsP
Participants, n2320
Age, years: mean (s.d.)39.8 (11.2)38.8 (9.9)0.84
Male, n (%)13 (56.5)12 (60.0)0.82
Ethnicity, n (%)
 Asian8 (34.8%)3 (15.0%)
 Black/African American2 (8.7%)5 (25.0%)
 Caucasian13 (56.5%)12 (60.0%)
Baseline scores,a mean (s.d.)
 HAMD22.0 (2.9)0.5 (1.1)<0.001
 HAMA20.7 (5.4)n/a
Week 12 scores,a mean (s.d.)
 HAMD6.9 (4.6)0.6 (1.3)<0.001
 HAMA7.5 (4.4)0.6 (1.1)<0.001
 Full IQ107.8 (10.7)109.2 (14.6)0.63
 Performance IQ103.2 (14.4)107.9 (15.2)0.3
 Verbal IQ110.0 (9.9)109.8 (12.4)0.95
  • HAMA, Hamilton Scale for Anxiety; HAMD, 17-item Hamilton Rating for Depression; MDD, major depressive disorder; n/a, not assessed.

  • a Ratings were acquired at baseline, during an acute depressive episode and following 12 weeks of treatment for patients, and at baseline and at the 12-week follow-up for healthy participants.