Table 2 Adjusted MMSE slopes (points/year) after Alzheimer’s disease diagnosis comparing those who received C-ACEIs and those who did not receive any ACEI
MMSE slopeReceived C-ACEIDid not receive ACEIMMSE slope difference (MMSE per year)P for group difference
First MMSE slope 0–9 months0.72 (0.89 to 0.55)0.19 (0.12 to 0.21)0.53 (0.05 to 1.01)0.037
Second MMSE slope 9–36 months−0.81 (−1.17 to −0.45)−0.68 (−1.54 to 0.18)−0.13 (−1.03 to 0.77)0.626
  • MMSE, Mini-Mental State Examination; C-ACEIs, centrally acting angiotensin converting enzyme inhibitors; ACEI, angiotensin converting enzyme inhibitor.